Compounds · 7 min read

NAD+ Biology: What Preclinical Studies Have Uncovered

Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous coenzyme present in every living cell, where it occupies a central position in cellular energy metabolism. Functioning as an electron shuttle, NAD+ participates in redox reactions spanning glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation. Importantly, NAD+ also serves as a consumable substrate for several families of signalling enzymes, giving it regulatory roles that extend well beyond bioenergetics.

NAD+ shuttles between its oxidized (NAD+) and reduced (NADH) states, and this interconversion lies at the heart of cellular ATP generation:

Research has documented age-associated declines in total NAD+ levels across multiple tissue types in both rodent and human studies, a finding that has sparked intense scientific interest in the causes and functional consequences of NAD+ depletion.

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